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Stamceller i oral cancer
Engelsk titel: Stem cells in oral cancer Läs online Författare: Nabil, Yalda ; Caballero Y Stuckas, Anais Jazmin ; Kleven, Maria Lyduch Språk: Dan Antal referenser: 18 Dokumenttyp: Översikt UI-nummer: 15063890

Tidskrift

Tandlaegebladet 2015;119(5)360-5 ISSN 0039-9353 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Oral cancer occurs in 7-8 per 100,000 inhabitants per year in Denmark. The average 5-year survival rate is 50 % and depends on the size of the tumour. In order to find new treatments there is research in the field of cancer stem cells, their occurrence, properties and mechanisms of action, as these cells are thought to be critical to cancer. Cancer is malignant and uncontrolled cell growth. 90 % of all cancers are carcinomas arising from healthy epithelial cells. In adults, stem cells are found in healthy tissues where their specific cell dividing pattern renews and maintains the tissue. In cancers, cancer stem cells are found to have similar characteristics to the normal stem cells, and it is suspected that cancer stem cells derive from their healthy equivalent. This makes it difficult to distinguish cancer stem cells from normal stem cells. Researchers are trying to find combinations of markers that are unique to cancer stem cells, hoping to isolate and target treatment against them. In the context of cancer metastasis there is research in cancer stem cells' ability to perform epithelial-to-mesenchymal transition (EMT), a process wherein the cell changes phenotype. Knowledge of the presence and function of stem cells in malignant tumours is essential for cancer treatment. Cancer stem cell presence complicates the current therapies and therefore treatment directed at them may show better results.