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Debate on HES safety is important, but must be based on facts
Engelsk titel: Debate on HES safety is important, but must be based on facts Läs online Författare: Haase, Nicolai ; Muller, Rasmus ; Perner, Anders Språk: Eng Antal referenser: 11 Dokumenttyp: Brev UI-nummer: 15069347


Sammanfattning

The Scandinavian Starch for Severe Sepsis / Septic Shock (6S) trial showed that hydroxyethyl starch was harmful compared to Ringer's acetate in patients with severe sepsis when used according to clinical practice and in alignment with the recommendations by the manufactures and authorities. The different interpretation by Chapell and Jacob's rely on misreading of the trial publication and is not supported by the trial data. Several hypotheses may be made regarding less harmful ways of using HES in critically ill patients, but clinicians, guideline committee members and authorities need to acknowledge that such safer ways have not yet been identified.