PET med amyloidligander bör ikke anvendes rutinemaessigt i tidlig diagnostik af Alzheimers sygdom - en gennemgang af et Cochranereview
Engelsk titel: PET with amyloid ligands should not be applied routinely in early diagnostics of Alzheimer’s disease
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Författare:
Hasselbalch, Steen Gregers
Email: steen.gregers.hasselbalch@regionh.dk
Språk: Dan
Antal referenser: 9
Dokumenttyp:
Artikel
UI-nummer: 15087591
Sammanfattning
Recent diagnostic criteria for Alzheimer’s disease incorporate biomarkers in order to increase the diagnostic accuracy. In a recent Cochrane review the ligand 11C-PiB
showed a high sensitivity, but low specificity for detecting patients with mild cognitive impairment who would develop Alzheimer’s dementia. Given the evolution of Alzheimer
pathology, these findings are not surprising. With current limited treatment options for MCI, 11C-PiB-PET cannot be recommended for routine use in MCI and should be used
only in selected cases where a positive scan will alter management.