Inget stöd för att lipidterapi är en effektiv antidot vid akut förgiftning. En systematisk litteraturöversikt och analys av 114 fallbeskrivningar
Engelsk titel: No support for lipid therapy as an effective antidote in acute intoxication. A systematic literature review and analysis of 114 case reports
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Författare:
Forsberg, Matilda
;
Forsberg, Sune
;
Höjer, Jonas
Email: Jonas.hojer@gic.se
Språk: Swe
Antal referenser: 40
Dokumenttyp:
Systematisk översikt
UI-nummer: 15117744
Sammanfattning
Lipid rescue is increasingly used as treatment of various types of poisoning despite weak scientific evidence. Some experimental studies have
confirmed a positive effect, but others have failed. Clinical studies are lacking, wherefore we decided to do a systematic review of all published human
cases. Case reports were searched for in PubMed and Web of Science and thereafter examined by two experts according to an assessment form
grading the probability for a causal connection between lipid rescue and improved symptoms. A total of 114 case reports were identified. No correlation
was found between the ratings of the cases and the fat solubility of the respective toxins. The findings do not support the predication that lipid rescue is
an effective antidote, not even in cases involving local anaesthetics. In view of the potentially negative effects of lipid rescue, it seems reasonable to
strictly limit its indication to life-threatening situations where conventional therapies have failed.