Sammanfattning
Melatonin has been shown to play a fundamental part in neuroimmunomodulation. Besides regulating the circadian rhythm it works as a natural antioxidant with immune stimulatory and anti-
cancer properties. Melatonin is a regulator of haemopoiesis and modifies various cells and cytokines of the immune system. Also, melatonin elicits oncostatic properties in a variety of different
tumour cell lines. A number of studies have documented that when given in combination with chemother-apy to patients with disseminated disease, melatonin increases the overall one-year
survival and reduces toxic side effects.