Anvendelse af monoaminooksidase-haemmeren isocarboxazid ved behandlingsresistent depression
Engelsk titel: The use of the monoamine oxidase inhibitor isocarboxazide in treatment-resistant depression
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Författare:
Larsen, Jens Knud
;
Krogh-Nielsen, Lene
;
Brösen, Kim
Email: jens.knud.larsen@ps.rm.dk
Språk: Dan
Antal referenser: 30
Dokumenttyp:
Översikt
UI-nummer: 16057419
Sammanfattning
The antidepressant efficacy of isocarboxazide is well established; however, the clinical use early became restricted and today the use of
isocarboxazide in Denmark is very limited. Isocarboxazide is safe when keeping a low tyramine-containing diet and avoiding concomitant
treatment with certain drugs. The risk of developing oedema can be reduced by vitamin B6 treatment. Normal dosage isocarboxazide may be
prescribed for all patients because isocarboxazide is not metabolized through the CYP2D6 enzyme complex like most other antidepressants. It
is recommended to include isocarboxazide in the official treatment algorithms for patients who are resistant to conventional antidepressant
therapy and electroconvulsive therapy.