Engelsk titel: Polyhexanide - safety and efficacy as an antiseptic
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Författare:
Fjeld, Hilde
;
Lingaas, Egil
Email: hilde.fjeld@ous-hf.no
Språk: Nor
Antal referenser: 43
Dokumenttyp:
Översikt
UI-nummer: 16077535
Sammanfattning
BACKGROUND Polyhexamethylene biguanide hydrochloride/polyhexanide/polyaminopropyl biguanide (PHMB) is used as a
disinfectant and antiseptic. This article discusses the use of the substance as an antiseptic. We summarise published data
on its antimicrobial efficacy in vitro and its clinical efficacy and safety when used on skin, wounds and mucosa.
MATERIAL AND METHOD A literature search was conducted in PubMed for articles published in the last five years. Articles
available as of June 2014 were considered.
RESULTS Of 332 articles identified, 27 were included. In vitro studies have demonstrated antimicrobial efficacy on gram-
negative bacteria, gram-positive bacteria and Candida albicans. The clinical trials are small-scale, not well controlled and
frequently sponsored by industry. Few adverse effects from the substance were reported.
INTERPRETATION Better designed, larger-scale clinical trials of efficacy and safety are needed in order to give
recommendations on the use of polyhexanide on skin, wounds and mucosa.