Energy balance and nutrient distribution in relation to CRP and HbA1c levels among patients with
type 2 diabetes
Sammanfattning
Background: Recently growing evidence indicates that obesity and diabetes are states of
inflammation associated with elevated circulation of inflammatory mediators. Excess adiposity and
oxidative stress, induced by feeding, may also lead to a state of low-grade inflammation.
Objective: This study aimed at investigating energy balance and distribution in relation to low-grade
inflammation among patients with type 2 diabetes.
Design: A cross-sectional study included 198 male and female patients with type 2 diabetes.
Patients’ weight, height, waist circumference, total body fat and truncal fat percent, energy, and
macronutrient intake were measured. Venous blood specimens were collected, and levels of HbA1c
and serum levels of high-sensitivity C-reactive protein (hs-CRP) were determined.
Results: After adjusting for covariates (body mass index, total body fat, and truncal fat), energy
balance was positively correlated with hs-CRP and HbA1c. A positive energy balance was also
associated with increased waist circumference and truncal fat percent (p<0.05). Total energy intake,
percent energy from fat (p=0.04), and percent energy from proteins (p=0.03), but not percent energy
from carbohydrates (p=0.12), were also correlated with higher hs-CRP levels among poorly
glycemic-controlled patients.
Conclusion: Positive energy balance is associated with elevations in hs-CRP. Increased energy
intake and increased percentages of energy from fat and protein are associated with elevated hs-CRP
among patients with poor glycemic control.