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Endogene retrovirus er associeret til autoimmune sygdomme
Engelsk titel: Endogenous retroviruses are associated with autoimmune diseases Läs online Författare: Nexö, Björn A ; Jensen, Sara B ; Hansen, Bettina ; Laska, Magdalena J Språk: Dan Antal referenser: 22 Dokumenttyp: Översikt UI-nummer: 16127145

Tidskrift

Ugeskrift for Laeger 2016;178(18)1702-5 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Retroviruses can be transmitted in two fundamentally different ways: 1) They can be horizontally transmitted as infectious virus, or 2) they can integrate in the germ line and be transmitted to offspring and the offsprings’ offspring as DNA. The latter is called endogenous viruses. The mode of transmission is called vertical. Viral variants of importance for development of disease must be more frequent among diseased persons than among healthy individuals. Multiple sclerosis, diabetes and rheumatoid arthritis are all associa­ted with sets of endogenouos retroviruses but not the same sets. If a virus grows and this contributes to disease, one should be able to alleviate disease with antiretroviral drugs. We call for clinical trials to elucidate this issue.