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Epigenetisk påvirkning af fosterets udvikling
Engelsk titel: Epigenetic influence on embryonic development Läs online Författare: Donkin, Ida ; Barres, Romain ; Pinborg, Anja Språk: Dan Antal referenser: 29 Dokumenttyp: Översikt UI-nummer: 17017305

Tidskrift

Ugeskrift for Laeger 2016;178(23)2196-9 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

The epigenome is sensitive to environmental changes and can sustainably alter gene expression, notably during embryonic development. New research indicates that epigenetic factors are heritable, which is why paternal lifestyle may affect fetal development and risk of disease. Children conceived by assisted reproduction technology (ART) have an increased risk of peri- and postnatal compli­cations, and as specific ART protocols associate with specific risk profiles, the procedures themselves may cause epigenetic changes contributing to the altered outcomes of the 5,000 Danish children annually conceived by ART.