Proprietary tomato extract improves metabolic response to high-fat meal in healthy normal weight subjects
Sammanfattning
Background: Low-density lipoprotein (LDL) oxidation is a risk factor for atherosclerosis. Lycopene and
tomato-based products have been described as potent inhibitors of LDL oxidation.
Objectives: To evaluate the effect of a 2-week supplementation with a carotenoid-rich tomato extract
(CRTE) standardized for a 1:1 ratio of lycopene and phytosterols, on post-prandial LDL oxidation after a
high-fat meal.
Design: In a randomized, double-blind, parallel-groups, placebo-controlled study, 146 healthy normal weight
individuals were randomly assigned to a daily dose of CRTE standardized for tomato phytonutrients or
placebo during 2 weeks. Oxidized LDL (OxLDL), glucose, insulin, and triglyceride (TG) responses were
measured for 8 h after ingestion of a high-fat meal before and at the end of intervention.
Results: Plasma lycopene, phytofluene, and phytoene were increased throughout the study period in the
CRTE group compared to placebo. CRTE ingestion significantly improved changes in OxLDL response to
high-fat meal compared to placebo after 2 weeks (pB0.0001). Changes observed in glucose, insulin, and TG
responses were not statistically significant after 2 weeks of supplementation, although together they may
suggest a trend of favorable effect on metabolic outcomes after a high-fat meal.
Conclusions: Two-week supplementation with CRTE increased carotenoids levels in plasma and improved
oxidized LDL response to a high-fat meal in healthy normal weight individuals.