En randomiseret klinisk undersögelse belyser ökologiske effekter af en tandpasta med enzymer og proteiner på plakkens mikrobiom
Engelsk titel: A randomised clinical study to determine the effect of a toothpaste containing enzymes and proteins on plaque oral microbiome ecology
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Författare:
Adams, Suzi E
;
Arnold, Dave
;
Murphy, Barry
;
Carroll, Pam
;
Green, Alison K
;
Smith, Adrtian M
;
Marsh, Philip D
;
Chen, Tsute
;
Marriott, Robert
;
Brading, Melanie G
Språk: Dan
Antal referenser: 103
Dokumenttyp:
RCT
UI-nummer: 17090195
Sammanfattning
The numerous species that make up the oral microbiome are
now understood to play a key role in establishment and maintenance
of oral health. The ability to taxonomically identify community
members at the species level is important to elucidating
its diversity and association to health and disease. We report the
overall ecological effects of using a toothpaste containing enzymes
and proteins compared to a control toothpaste on the
plaque microbiome. The results reported here demonstrate that
a toothpaste containing enzymes and proteins can augment
natural salivary defences to promote an overall community shift
resulting in an increase in bacteria associated with gum health
and a concomitant decrease in those associated with periodontal
disease. Statistical analysis shows significant increases in 12 taxa
associated with gum health including Neisseria spp. and a significant
decrease in 10 taxa associated with periodontal disease
including Treponema spp. The results demonstrate that a toothpaste
containing enzymes and proteins can significantly shift the
ecology of the oral microbiome (at species level) resulting in a
community with a stronger association to health.