The probable role of adrenomedullin and nitric oxide in childhood attention deficit hyperactivity disorder
Sammanfattning
Background: The role of adrenomedullin hormone, which has been shown to be associated with
many psychiatric disorders, in the etiology of ADHD and its relation to disease is not yet known.
Aim: In this study, it was aimed to compare plasma adrenomedullin and nitric oxide (NO) levels of
newly diagnosed, treatment-naive patients with ADHD with healthy children.
Methods: A total of 45 children with ADHD and 45 healthy children were included. The Schedule for
Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS), a semi-structured interview,
was applied to all cases by child and adolescent psychiatrist. Age and gender matched participants
who admitted to the hospital for any other reasons without any psychiatric diagnosis according
to K-SADS were selected as a control group. Sociodemographic data form and The Turgay DSM-IVBased
Child and Adolescent Disruptive Behavioral Disorders Screening and Rating Scale-parental form
were applied to the all groups. NO and adrenomedullin levels were analysed by ELISA method with
specific commercial kits.
Results: There was no statistically significant difference in NO and adrenomedullin levels, neither
between the groups nor ADHD subtypes. A positive correlation between adrenomedullin and NO levels
was found in both the case (r ¼ 0.659) and the control groups (r ¼ 0.494).
Conclusions: Besides being the first study to evaluate adrenomedullin levels to elucidate the etiology
of childhood ADHD as well as NO, significant differences was not found between the case and the
control groups in terms of NO and adrenomedullin levels.