A 50-bp Ins/Del polymorphism at the promoter region of the superoxide dismutase-1 and bipolar disorder type 1
Engelsk titel: A 50-bp Ins/Del polymorphism at the promoter region of the superoxide dismutase-1 and bipolar disorder type 1
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Författare:
Kordestanian, Nazanin
;
Saadat, Mostafa
Email: saadat@shirazu.ac.ir
Språk: Eng
Antal referenser: 29
Dokumenttyp:
Artikel
UI-nummer: 18020218
Sammanfattning
Bipolar disorder type 1 (BPD) is a chronic psychiatric illness and is associated with oxidative stress.
Superoxide dismutase-1 (SOD1; OMIM: 147450) metabolizes highly reactive and more dangerous superoxide
radicals into less reactive molecules. A functional 50-bp insertion/deletion (Ins/Del) polymorphism
in the promoter region of the gene has been reported. The primary aim of the current case–control
study was to explore whether the SOD1 Ins/Del polymorphism associated with the risk of BPD. A secondary
aim was to investigate the association between the study polymorphism and age of onset of
BPD. The present case–control study was performed in Shiraz (southern Iran) on 228 BPD and 224
healthy blood donor controls. The genotypes of the SOD1 Ins/Del polymorphism were determined by
polymerase chain reaction. There was no significant association between the genotypes of Ins/Del
polymorphism and the risk of BPD. Using Cox proportional hazards regression model, after adjustment
for family history of BPD, revealed a significant association between the SOD1 Ins/Del polymorphism
and age of onset. The age of onset was significantly lower for the Del/Del genotype than the
‘Ins/Ins þ Ins/Del’ genotypes (hazard ratio ¼ 2.33, 95%CI: 1.08–5.02, p ¼ .030). Our present findings
revealed that although the SOD1 Ins/Del polymorphism was not associated with the risk of BPD, it was
significantly associated with age of onset of BPD.