Engelsk titel: Genetics – Are substantial effects documented in schizophrenia?
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Författare:
Fosse, Roar
Email: roar.fosse@vestreviken.no
Språk: Nor
Antal referenser: 76
Dokumenttyp:
Artikel
UI-nummer: 18030112
Sammanfattning
Genetic research on schizophrenia started out with a focus on candidate genes, but with limited success. Subsequent studies have searched for schizophrenia-associated single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) anywhere on the genome. In genome wide association studies (GWAS), SNPs with a small but statistically significant difference in prevalence between schizophrenia and normal healthy controls have been identified at 108 independent positions on DNA, accounting for 3,4 % of liability to the disorder. CNVs appear to account for an additional 1 % of liability but are unspecific for schizophrenia. Sum scores of genetic risk based on SNPs from GWAS are used to investigate associations with underlying symptom dimensions and neurobiological and cognitive traits, but substantial associations remain to be identified. The current molecular genetic evidence does not support a view of schizophrenia as strongly genetically based.