Engelsk titel: Prevalence of diabetes before and after first diagnosis of coronary artery disease
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Författare:
Kaldal, Anete
;
Jortveit, Jarle
;
Tonstad, Serena
Email: jarle.jortveit@sshf.no
Språk: Nor
Antal referenser: 27
Dokumenttyp:
Artikel
UI-nummer: 18040037
Sammanfattning
BACKGROUND: Diabetes is associated with coronary artery disease, and cardiovascular disease is the main cause of death in persons with the disease. In this study we have investigated the prevalence of known and undiagnosed diabetes in patients with initial myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft as well as the incidence of subsequent cardiovascular events for a period of up to five years afterwards.
MATERIAL AND METHOD: All patients < 80 years of age with no previously known coronary artery disease who were hospitalised at Sørlandet Hospital Arendal in connection with initial myocardial infarction, percutaneous coronary intervention or coronary artery bypass graft in the period 2007–16 were added consecutively to the study and followed for up to five years (median follow-up time three years).
RESULTS: Of the 1 259 patients included, 178 (14 %) had known diabetes at the time of hospitalisation and 49 (4 %) had undiagnosed diabetes. A further 102 patients (8 %) developed diabetes during the follow-up period. Approximately half of those with diabetes had an HbA1c value of ≤ 7 %. The risk of subsequent cardiovascular events developing was higher in patients with diabetes than in patients without diabetes (age- and gender-adjusted hazard ratio 1.5; 95 % confidence interval: 1.1–2.1, p = 0.005).
INTERPRETATION: The study shows a high prevalence of diabetes in patients with a first diagnosis of coronary artery disease and a high risk of subsequent cardiovascular events in patients with diabetes. Regular monitoring for the development of diabetes and good prophylactic treatment of patients with diabetes and coronary artery disease are essential.