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Background: Quality of life, coping strategies, social support and self‐efficacy are important psychosocial variables strongly affecting the experience of acute myocardial infarction (AMI) in women. Aims: To gain a more in‐depth understanding of how coping strategies, self‐efficacy, quality of life and social support shape women's adjustment to AMI. Design: Mixed methods study. Quantitative data were collected through a standardised questionnaire on coping strategies, self‐efficacy, quality of life and social support. Qualitative data stemmed from 57 semistructured interviews conducted with post‐AMI female patients on related topics. Methods: Quantitative data were analysed with unpaired two‐sample t‐tests on the means, comparing women who experienced AMI (N = 77) with a control group of women who did not have AMI (N = 173), and pairwise correlations on the AMI sample. Qualitative data were grouped into coding families and analysed through thematic content analysis. Qualitative and quantitative results were then integrated, for different age groups. Results: Quantitative results indicated statistically significant differences between women who experienced AMI and the control group: the former showed lower self‐perceived health, perceived social support and social support coping, but greater self‐efficacy, use of acceptance, avoidance and religious coping. Pairwise correlations showed that avoidance coping strategy was negatively correlated with quality of life, while the opposite was true for problem‐oriented coping, perceived social support and self‐efficacy. Qualitative results extended and confirmed quantitative results, except for coping strategies: avoidance coping seemed more present than reported in the standardised measures. Conclusion: Mixed methods provide understanding of the importance of social support, self‐efficacy and less avoidant coping strategies to women's adjustment to AMI. Published by arrangement with John Wiley & Sons.

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