Orale Lactobacillus som praediktor for udvikling af overvaegt: Et seksårs opfölgningsstudie
Sammanfattning
Recent studies have shown an association
between weight change and the makeup of the intestinal
microbiota in humans. Specifically, Lactobacillus, a part of
the entire gastrointestinal tract’s microbiota, has been shown
to contribute to weight regulation.
AIM – We examined the association between the level of oral
Lactobacillus and the subsequent 6-year weight change in
a healthy population of 322 Danish adults aged 35-65 years
at baseline.
DESIGN – Prospective observational study
RESULTS – In unadjusted analysis the level of oral Lactobacillus
was inversely associated with subsequent 6-year change
in BMI (Body Mass Index). A statistically significant interaction
between the baseline level of oral Lactobacillus and the
consumption of complex carbohydrates was found, eg. high
oral Lactobacillus count predicted weight loss for those with
a low intake of complex carbohydrates, while a medium intake
of complex carbohydrates predicted diminished weight
gain. A closer examination of these relations showed that
BMI change and Lactobacillus level was unrelated for those
with high complex carbohydrate consumption.
CONCLUSION – A high level of oral Lactobacillus seems related
to weight loss among those with medium and low intakes
of complex carbohydrates. Absence, or a low level of oral
Lactobacillus, may potentially be a novel marker to identify
those at increased risk of weight gain.