Engelsk titel: The brain’s biological clock
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Författare:
Fahrenkrug, Jan
Email: jan.fahrenkrug@regionh.dk
Språk: Dan
Antal referenser: 27
Dokumenttyp:
Översikt
UI-nummer: 19010304
Sammanfattning
Daily biological rhythms are controlled by a clock system, composed of a hierarchical multi-oscillator structure. Each cell in this system harbours a self-sustained autonomous molecular oscillator. Light adjusts the phase of the brain oscillator to the environmental light/dark cycle by intrinsically photosensitive retinal ganglion cells through their own photoreceptor, melanopsin, and by using the neuropeptide called pituitary adenylate cyclase-activating polypeptide as well as glutamate as neurotransmitters. The circadian synchronisation system is critical to health, and breakdown of the 24-hours temporal order could lead to pathological conditions.