Engelsk titel: Genomic medicine as consumer goods
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Författare:
Folkersen, Lasse
;
Werge, Thomas
Email: lasse.folkersen@regionh.dk
Språk: Dan
Antal referenser: 16
Dokumenttyp:
Översikt
UI-nummer: 19050338
Sammanfattning
In this review, current trends in personal genetics are covered. The main differences between the “classic” rare high-effect mutations vs. the combined effects of thousands of common, low-risk variants are outlined, and then we provide examples of possible clinical use of microarray-based genetic measurements of rare high-risk mutations, and diagnosis-specific polygenic risk scores. The aim of this review is to discuss the possible clinical relevance vs. the hyped and potentially harmful overinterpretations of direct-to-consumer genetics services.