Engelsk titel: A fragment of collagen XVIII inhibits angiogenesis
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Författare:
Zätterström UK
;
Fukai N
;
Olsen BR
Språk: Nor
Antal referenser: 21
Dokumenttyp:
Översikt
UI-nummer: 00122416
Sammanfattning
BACKGROUND : Malignant tumours may produce substances with both stimulatory and inhibitory effect on angiogenesis.
MATERIAL AND METHODS : A protein fragment with angiogenesis-inhibiting potential was recently identified in conditioned media from a murine endothelial tumour cell line.
RESULTS : The angiogenesis inhibitor, endostatin, is a 20 kDa C-terminal fragment of collagen XVIII, a proteoglycan/collagen found in vessel walls and basement membranes. The generation of endostatin or endostatin-like collagen XVIII fragments is catalyzed by proteolytic enzymes, including cathepsin L and matrix metalloproteases, that cleave peptide bonds within the protease-sensitive hinge region of the C-terminal domain.
INTERPRETATION : The physiological processing of collagen XVIII to endostatin may represent a local control mechanism for the regulation of angiogenesis. The outcome of ongoing clinical trials will determine the role of endostatin as a possible angiogenesis-inhibiting drug in the future.