Engelsk titel: Etiology of non-melanoma skin cancer
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Författare:
Gjersvik PJ
Email: petter.gjersvik@rikshospitalet.no
Språk: Nor
Antal referenser: 29
Dokumenttyp:
Översikt
UI-nummer: 01071519
Sammanfattning
BACKGROUND : Most countries are experiencing an increased incidence of non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma).
MATERIAL AND METHODS : Based on relevant literature found by search in the PubMed database, an overview of the present knowledge of the etiology and pathogenesis of non-melanoma skin cancer is given.
RESULTS : DNA damage caused by ultraviolet (UV) radiation from the sun is the main cause of non-melanoma skin cancer. Failure to repair these genetic alterations leads to unrestrained growth and ultimately tumour formation. In addition, ultraviolet radiation induces a relative immunosuppression in the skin that prevents cutaneous tumour rejection. UV-specific mutations in the p53 tumour suppressor gene probably play an important role through both tumour initiation and cell selection.
INTERPRETATION : Physicians should advise their patients to avoid unnecessary sun exposure and to use sun protection, including sun screen creams.