Indlösning af en ny antibiotikumrecept efter behandling med sulfonamid eller pivmecillinam. En
receptundersögelse blandt 15-50-årige kvinder i Nordjyllands Amt
Engelsk titel: Repeat antibiotic prescriptions following treatment with sulfonamide or pivmecillinam. A survey of
prescriptions among women aged 15-50 years in the county of Nordjylland
Läs online
Författare:
Schönheyder HC
;
Thrane N
;
Toft Sörensen H
Email: prof1@aas.nja.dk
Språk: Dan
Antal referenser: 22
Dokumenttyp:
Artikel
UI-nummer: 02011541
Sammanfattning
Introduction: A sulphonamide is the antibiotic of first choice for the treatment of uncomplicated urinary tract infections in Denmark. However, this recommendation has been challenged. Material and methods: The study comprised 9,224 women, aged 15 to 50 years, who were residents in the County of North Jutland, Denmark. During 1997-1998 they had handed in a prescription from a general practitioner for either sulphonamide or pivmecillinam, but no other prescriptions for antibiotics during the preceding six months. Any antibiotic prescription handed in within the ensuing 31-day period was recorded, with the exception of macrolides. The proportion of women with a repeat prescription was a proxy for therapeutic failure. Results: Eight thousand two hundred and sixty-nine women (89.6%) had handed in a prescription for a sulphonamide and 955 (10.4%) a prescription for pivmecillinam. A total of 1,490 women (16.2%) handed in a repeat prescription, i.e. 16.0% (95% confidence limits [CI] 15.2-16.8%) of women treated with sulphonamide and 17.8% (95% CI 15.4-20.4%) of women treated with pivmecillinam. The relative risk of a repeat prescription was 1.11 (95% CI 0.95-1.31) for women with a primary prescription for pivmecillinam, as compared to women with a sulphonamide prescription. Women who had handed in a sulphonamide prescription for less than three defined daily doses had an increased risk of a repeat prescription. Discussion: The proportion of women with a repeat prescription did not differ much between women treated with sulphonamide and those treated with pivmecillinam. Controlled clinical trials should be performed before revision of current Danish recommendations are considered.