Engelsk titel: Genetic aspects of Alzheimer disease
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Författare:
Öksengård AR
;
Engedal K
Email: a.r.h.oksengard@ioks.uio.no
Språk: Nor
Antal referenser: 21
Dokumenttyp:
Översikt
UI-nummer: 02031961
Sammanfattning
INTERPRETATION : Children of patients with Alzheimer's disease have a three to four fold increased risk of developing the disease compared to a person without a parent with Alzheimer's disease. The diagnostic benefit of apolipoprotein E genotyping is still uncertain.
RESULTS : Two well-known risks for developing Alzheimer's disease are established: advanced age and genetic factors. Mutations linked to autosomal dominant familial Alzheimer's disease are known in chromosomes 21, 14 and 1. A non-mendelian Alzheimer's disease with complex aetiology is linked to the apolipoprotein E in chromosome 19.
MATERIALS AND METHODS : Data from the literature (Medline) and personal experiences.
BACKGROUND : To supply relevant information about the genetics of Alzheimer's disease.