Engelsk titel: Dinitrophenol - a dangerous doping agent
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Författare:
Sand P
;
Madsen S
Email: steinar.madsen@legemiddelverket.no
Språk: Nor
Antal referenser: 10
Dokumenttyp:
Fallbeskrivning
UI-nummer: 02071753
Sammanfattning
BACKGROUND : Performance-enhancing drugs are frequently used by bodybuilders: anabolic steroids, growth hormone and insulin, only to mention a few. Many little known drugs are also used.
MATERIAL AND METHODS : Two men aged 20 and 32 years, both active bodybuilders, complained about lassitude and malaise. Clinical and laboratory evaluation revealed an unusual cause of their complaints.
RESULTS : Laboratory investigation showed very low serum levels of free thyroxin and thyroid stimulating hormone (TSH), suggesting central depression of thyroid function. Both men then admitted taking dinitrophenol (approximately 5 mg/kg bodyweight/day) to "burn fat" before body-building competitions.
INTERPRETATION : Doctors should be aware that bodybuilders might use dinitrophenol. This toxic compound has severe metabolic effects. Overdose may cause hyperpyrexia and death. Use should be strongly discouraged.