Apoptose ved kronisk inflammatorisk tarmsykdom. Betydning for patogenese og behandling
Engelsk titel: Apoptosis in chronic inflammatory bowel disease. The importance for pathogenesis and treatment
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Författare:
Seidelin JB
;
Haagen Nielsen O
Email: jakse@herlevhosp.kbhamt.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Översikt
UI-nummer: 03021152
Sammanfattning
Inflammatory bowel disease (IBD) is characterized by the increased survival of lamina propria leucocytes and ulcerations and an increased epithelial leakiness that compromise the barrier function of the epithelial lining. Deregulated apoptosis seems to be a major cause of the impaired barrier function and of leucocyte survival. This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed.