Molekylaere mekanismer bag den immunologiske reaktion mod gluten hos patienter med cöliaki
Engelsk titel: Molecular mechanisms behind the immunological reaction against gluten in patients with celiac
disease
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Författare:
Nielsen C
;
Husby S
;
Lillevang ST
Språk: Dan
Antal referenser: 7
Dokumenttyp:
Artikel
UI-nummer: 03031202
Sammanfattning
Coeliac disease is a complex inflammatory disorder of the small intestine, induced by dietary gluten in genetically susceptible individuals. Recently, the nature of gluten-derived peptides recognized by gut-derived T cells from patients has been elucidated. It has further been established that the binding of such peptides to HLA-DQ2 and DQ8 molecules is enhanced following the modification of the peptides by the ubiquitous enzyme tissue transglutaminase. This knowledge has allowed the establishment of a molecular basis for the well-known association between coeliac disease and the expression of these HLA-molecules. This article summarizes the latest progress in coeliac disease molecular biology.