Beskytter vitamin C og E mot utvikling av carotisstenose og kardiovaskulaere sykdommer?
Engelsk titel: Do vitamins C and E protect against the development of carotid stenosis and cardiovascular disease?
Läs online
Författare:
Landmark K
;
Reikvam Å
Email: k.h.landmark@labmed.uio.no
Språk: Nor
Antal referenser: 49
Dokumenttyp:
Översikt
UI-nummer: 05011947
Sammanfattning
BACKGROUND : Some observational and randomized, clinical interventional studies have indicated that the antioxidative vitamins C (ascorbic acid) and E (alpha-tocopherol) can reduce intima-media thickness of the carotid arteries. It is, however, not clarified whether these vitamins may have a preventive effect against cardiovascular events.
MATERIAL AND METHODS : The literature on the effects in relation to several cardiovascular endpoints of vitamins C and E, also used in combination, has been evaluated. The literature has been continuously and systematically collected over many years and supplemented by recent studies retrieved from Medline.
RESULTS : Observational studies including mainly healthy individuals have shown a favourable relationship between intake of vitamins C and E, also taken in combination, and subsequent cardiovascular events. However, most randomized, clinical interventional studies including patients with manifest atherosclerotic disease have not been able to document such a relationship.
INTERPRETATION : The discrepancy found between observational studies and clinical interventional studies may be due to different study populations (healthy/ill individuals) and differences regarding age, sex, diet, smoking, degree of oxidative stress and other probable confounding factors. The significance of vitamins C and E in preventing cardiovascular disease is in our opinion not yet clarified.