Engelsk titel: Liver cirrhosis and bacterial infections
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Författare:
Vilstrup H
Email: vilstrup@as.aaa.dk
Språk: Dan
Antal referenser: 11
Dokumenttyp:
Artikel
UI-nummer: 05021115
Sammanfattning
The mortality rate of infections in patients with cirrhosis is more than 20 times that in the general population. Both the host's defense system and the systemic response to infection are compromised, and the microbiotic invasion, often of an opportunistic nature, is augmented due to intestinal translocation, aspiration, and other factors. Infection should be suspected in any cirrhotic patient with a deteriorating clinical course, and treatment with large doses of broad-spectrum anti biotics, avoiding aminoglycosides, should be promptly initiated. Antibiotic prophylaxis carries a high risk of colonization with resistant strains but reduces the mortality rate from upper gastrointestinal bleeding and recurrent spontaneous bacterial peritonitis.