Engelsk titel: Molecular biology in the diagnosis of lung cancer
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Författare:
Haugen A
Email: age.haugen@stami.no
Språk: Nor
Antal referenser: 15
Dokumenttyp:
Översikt
UI-nummer: 05121208
Sammanfattning
MATERIALS AND METHODS : Research articles and reviews.
BACKGROUND : Lung cancer is the most prevalent and deadly cancer in the world. Despite extensive efforts made in the development of diagnostic methods, the overall five-year survival rate remains low.
RESULTS AND INTERPRETATION : Significant progress has been made in understanding the molecular and cellular mechanisms and pathogenesis in lung cancer. In addition to abnormalities in proto-oncogenes and tumour suppressor genes, aberrant promoter hypermethylation is now recognised as an important component in lung cancer progression. Sensitive assays have been developed to assess promoter methylation in biological fluids that may be used in screening programmes and diagnosis of lung cancer. The development of gene expression profiling techniques has led to new approaches to lung cancer classification and diagnosis.