Engelsk titel: Increasing antibiotic resistance in urinary tract infections
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Författare:
Skudal HK
;
Grude N
;
Kristiansen BW
Email: hilde.skudal@akersykehus.no
Språk: Nor
Antal referenser: 12
Dokumenttyp:
Artikel
UI-nummer: 06041083
Sammanfattning
BACKGROUND : There is increasing focus on the development of bacterial antibiotic resistance.
MATERIALS AND METHODS : We conducted a retrospective study of urine samples from patients resident in a Norwegian county, comparing 9121 samples culture-positive in 2003-04 with 28 066 samples in 1997-99. Determination of resistance was done with the MAST automatic multipoint inoculator system.
RESULTS : Escherichia coli was found in 68% and 56% of out-patient and in-patient isolates respectively. Significant declines in mecillinam sensitivity (from 96% to 94%), nitrofurantoin sensitivity (from 97% to 95%) and sulfonamide sensitivity (from 73% to 71%) in in-patient E. coli isolates were found. In out-patients we found significant reductions in sensitivity to ampicillin (from 78% to 76%) and trimethoprim (from 83% to 82%). For urinary tract infection isolates as a whole, the greatest sensitivity was observed for nitrofurantoin: 85% in in-patient isolates and 75% in out-patient isolates, but there was a significant decline in resistance to several antibiotics.
INTERPRETATION : Increasing antibiotic resistance may be related to increasing antibiotic use. Mecillinam and nitrofurantoin may be considered first-choice preparations as E. coli is the dominant etiological agent and shows the greatest sensitivity to these two antibiotics.