Engelsk titel: Does 5-aminosalicylic acid prevent development of colon cancer in ulcerative colitis?
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Författare:
Fallingborg JF
Email: u19017@aas.nja.dk
Språk: Dan
Antal referenser: 9
Dokumenttyp:
Översikt
UI-nummer: 06051307
Sammanfattning
Several case control studies have demonstrated that in patients with ulcerative colitis, ingestion of 5-ASA is correlated with a reduced risk of developing colon cancer. A recent editorial in The American Journal of Gastroenterology concluded that "a 5-ASA tablet a day keeps the cancer away". However, the clinical studies in the meta-analysis upon which this conclusion is based are relatively small, and confounding could explain the observed correlation. A large study in which a chemoprotective effect of 5-ASA could not be found has been presented but has not yet been published. It would be advisable to wait for further documentation before 5-ASA is prescribed for chemo prevention of colonic cancer.