Engelsk titel: Cancer-protecting genes (tumor-suppressor genes)
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Författare:
Olsen J
Email: jolsen@imbg.ku.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Artikel
UI-nummer: 06061408
Sammanfattning
Tumor-suppressor genes protect against the development of cancer. The prototypical tumor-suppressor gene is one that controls G1 to S progression in the cell cycle. However, genes that are involved in DNA-repair or induction of apoptosis also protect against the development of cancer. More generally speaking, tumor-suppressor genes either prevent the introduction of somatic mutations or the amplification of the population of somatic cells carrying mutations. Well-known tumor-suppressor genes that also give rise to inherited cancer disorders are described in the review.