Sök artiklar i SveMed+

Observera: SveMed+ upphör att uppdateras!



Cancerbeskyttende gener (tumorsuppressorgener)
Engelsk titel: Cancer-protecting genes (tumor-suppressor genes) Läs online Författare: Olsen J Språk: Dan Antal referenser: 10 Dokumenttyp: Artikel UI-nummer: 06061408

Tidskrift

Ugeskrift for Laeger 2006;168(24)2329-31 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Tumor-suppressor genes protect against the development of cancer. The prototypical tumor-suppressor gene is one that controls G1 to S progression in the cell cycle. However, genes that are involved in DNA-repair or induction of apoptosis also protect against the development of cancer. More generally speaking, tumor-suppressor genes either prevent the introduction of somatic mutations or the amplification of the population of somatic cells carrying mutations. Well-known tumor-suppressor genes that also give rise to inherited cancer disorders are described in the review.