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Arvelig cancer mammae et cancer ovarii
Engelsk titel: Inherited breast and ovarian cancers Läs online Författare: Gerdes AM ; Ejlertsen B Språk: Dan Antal referenser: 10 Dokumenttyp: Artikel UI-nummer: 06061418

Tidskrift

Ugeskrift for Laeger 2006;168(24)2367-9 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Most breast and ovarian cancers are sporadic, but approximately 5% are the result of inherited predisposition. Patients and their families may, through genetic risk assessment, be classified as subject to hereditary breast and/or ovarian cancers with an autosomal dominant inheritance. Mutations in the BRCA1 and BRCA2 genes have been identified in most breast and ovarian cancer families, although other genes may be involved. National guidelines for clinical intervention in the cases of high-risk individuals have been established.