Engelsk titel: Bivalirudin: a direct thrombin inhibitor in percutaneous coronary interventions
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Författare:
Riis Hansen P
Email: prh@dadlnet.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Översikt
UI-nummer: 06091938
Sammanfattning
Bivalirudin is a direct thrombin inhibitor that has biological and pharmacokinetic advantages over heparin, e.g., by inhibiting both fibrin-bound and -unbound thrombin. In patients undergoing subacute or elective percutaneous coronary intervention, bivalirudin + provisional glycoprotein IIb/IIIa inhibition is as effective as unfractionated heparin + glycoprotein IIb/IIIa inhibition and is associated with a reduced risk of bleeding. The results of ongoing trials will further define the promising role of bivalirudin in the treatment of patients with acute coronary syndromes.