Engelsk titel: Phosphatidylethanol in blood (B-PEth) - a new marker of alcohol abuse
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Författare:
Hansson T
;
Isaksson A
;
Walther L
;
Alling C
Email: anders.isaksson@skane.se
Språk: Swe
Antal referenser: 22
Dokumenttyp:
Fallbeskrivning
UI-nummer: 09041540
Sammanfattning
Phosphatidylethanol (PEth) is an abnormal phospholipid that is formed only in the presence of alcohol (ethanol). Hence, the diagnostic specificity of PEth as an alcohol marker is theoretically 100 %. No false positive results have been recorded.
When more than moderate amounts of alcohol are regularly consumed, blood cells become enriched with PEth. Regular consumption for at least one week appears to be needed to give measurable amounts of PEth. There is a positive correlation between the amount of alcohol consumed and blood concentration of PEth. PEth has been shown to be a more sensitive indicator of alcohol consumption than CDT (Carbohydrate-deficient transferrin), GGT (Gamma-glutamyl transferase) and MCV (Mean corpuscular volume) or a combination of these. The half life of PEth in circulation is about 4 days, which means that PEth can be detected up to 4 weeks after ethanol has been cleared from the body.