Engelsk titel: Biomarkers in cerebrospinal fluid and blood in memory complaints
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Författare:
Zetterberg H
;
Andreasen N
;
Blennow K
Email: henrik.zetterberg @clinchem.gu.se
Språk: Swe
Antal referenser: 52
Dokumenttyp:
Översikt
UI-nummer: 09051744
Sammanfattning
Neurodegenerative diseases are characterised by neuronal disintegration that is reflected in the protein composition of cerebrospinal fluid. Alzheimer's disease is characterised by changes in amyloid and tau protein metabolism in the brain, which is strongly linked to the disease process. Amyloid and tau proteins can be measured in cerebrospinal fluid and hold both diagnostic and prognostic information. Specific biomarkers for other neurodegenerative disorders are still lacking, although novel candidates are being evaluated, including _-synuclein and TAR DNA-binding protein 43. In addition to specific biomarkers,it is of great importance to assess patients with memory complaints for cerebrospinal fluid changes typical of neuroinflammatory or neuroinfectious disorders. These analyses include cerebrospinal fluid cell count, albumin ratio and measures of intrathecal immunoglobulin synthesis. This review gives an updated overview of cerebrospinal fluid analyses in patients with memory complaints. We also summarise the latest progress with regards to novel cerebrospinal fluid candidate biomarkers and biomarkers in peripheral blood.