Kalprotektin i feces bra markör för gastrointestinal inflammation. Visar på sjukdomsintensitet - normaliserade värden talar för slemhinneläkning
Engelsk titel: Calprotectin in feces a well-documented marker of gastrointestinal inflammation. Indicates disease intensity - normalization of values predict mucosal healing
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Författare:
Lasson, Anders
Email: anders.lasson@vgregion.se
Språk: Swe
Antal referenser: 37
Dokumenttyp:
Översikt
UI-nummer: 10101042
Sammanfattning
In this review the clinical use of calprotectin as a faecal marker of intestinal inflammation is discussed. Faecal calprotectin is a well-documented marker of gastrointestinal inflammation. It is useful as a noninvasive screening tool to differentiate functional from organic bowel pathology. A normal value of faecal calprotectin supports a clinical suspicion of irritable bowel syndrome. In ulcerative colitis and Crohns disease faecal calprotectin correlates closely with disease activity, and normalization of faecal calprotectin is a predictor of mucosal healing. Further, faecal calprotectin is a predictor of relapse in patients with inflammatory bowel disease. Slightly or moderately elevated values of calprotectin can be difficult to interpret and should be judged along with the patients clinical presentation.