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Metaanalyse af farmakologisk alkoholmisbrugsbehandling med acamprosat, naltrexon og disulfiram
Engelsk titel: Meta-analysis of pharmacological therapy with acomprosate, naltrexone, and disulfiram Läs online Författare: Petrov, Igor ; Krogh, Jesper ; Nordentoft, Merete Språk: Dan Antal referenser: 40 Dokumenttyp: Metaanalys ; Översikt UI-nummer: 11121361

Tidskrift

Ugeskrift for Laeger 2011;173(48)3103-9 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift

Sammanfattning

The meta-analysis is based on 16 randomized controlled trials of acamprosate, 18 of naltrexone and 7 of disulfiram. Acamprosate and naltrexone were 52% (RR = 1.52; 95% confidence interval (CI): 1.35-1,72) and 27% (RR = 1.27; 95% CI: 1,06-1,52) better than placebo when it came to supporting continuous abstinence. Acamprosate increased the total number of abstinence days with 14% (MD = 14.02; 95% CI: 9.57-18.47). Disulfiram appeared to be effective only when the intake was supervised. Based on the amount of scientific evidence, acamprosate and naltrexone therapy should be increased in clinical practice in the treatment of alcoholism.



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