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Engelsk titel: Adverse events associated with long-term use of proton pump inhibitors
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Författare:
Reimer, Christina
;
Bytzer, Peter
Email: pmby@regionsjaelland.dk
Språk: Dan
Antal referenser: 29
Dokumenttyp:
Artikel
UI-nummer: 12107463
Sammanfattning
Proton pump inhibitors (PPI) remain the leading therapy for acid-related disorders. Long-term PPI use increases the risk of pneumonia and enteric bacterial infections and of nosocomial Clostridium difficile-associated diarrhoea. PPIs do not lead to vitamin B12 or iron deficiencies and do not induce malignancies or increase the risk of major birth defects. Prolonged PPI use may be a weak risk factor for certain fractures and results in hypergastrinaemia and parietal cell hyperplasia leading to rebound acid hypersecretion, which may induce symptoms on withdrawal of therapy.