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5-aminolevulinsyre-fluorescens-vejledt resektion af maligne gliomer er en ny behandlingsmodalitet
Engelsk titel: Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas - a new treatment modality Läs online Författare: Cortnum, Sören ; Laursen, Rene Språk: Dan Antal referenser: 17 Dokumenttyp: Översikt UI-nummer: 13047170

Tidskrift

Ugeskrift for Laeger 2013;175(9)570-3 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)

Sammanfattning

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant gliomas - a new treatment modality Ugeskr Læger 2013;175(9):570-573 5- aminolevulinic acid (ALA) is a precursor of haemoglobin which leads to the synthesis of porphyrins in malignant gliomas which then appears with red fluorescence under blue light. In the literature we see that there is class Ib evidence that 5-ALA guided surgery significantly increases the radicalism of surgery and gives rise to a marked improvement in 6-month progression-free survival and that there is now class II evidence confirming the value of maximal cytoreductive surgery. Furthermore, existing class II evidence indicates that there is a synergistic effect between aggressive cytoreductive surgery and radiochemotherapy.