Engelsk titel: Wheat aleurone polyphenols increase plasma eicosapentaenoic acid in rats
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Författare:
Ounnas, Faycal
;
Prive, Florence
;
Salen, Patricia
;
Hazane-Puch, Florence
;
Laporte, Francois
;
Fontaine, Eric
;
Del Rio, Daniele
;
Calani, Luca
;
Melegari, Camilla
;
Bianchi, Marta Angela
;
Demeilliers, Christine
;
de Lorgeril, Michel
Email: ounnasf@ujf-grenoble.fr
Språk: Eng
Antal referenser: 18
Dokumenttyp:
Artikel
UI-nummer: 14103698
Sammanfattning
Methods: These studies were designed to assess whether wheat polyphenols (mainly ferulic
acid [FA])
increased the very-long-chain omega-3 fatty acids (VLC n-3) [eicosapentaenoic acid (EPA) and
docosahexaenoic
acid (DHA)] in rats. Wheat aleurone (WA) was used as a dietary source of wheat polyphenols. Two
experiments were performed; in the first one, the rats were fed WA or control pellets (CP) in presence
of
linseed oil (LO) to provide alpha-linolenic acid (ALA), the precursor of VLC n-3. In the second one, the
rats
were fed WA or CP in presence of control oil (CO) without ALA. The concentrations of phenolic acid
metabolites in urine were also investigated.
Results: The urinary concentration of conjugated FA increased with WA ingestion (pB0.05). Plasma
EPA
increased by 25% (pB0.05) with WA in the CO group but not in the LO group. In contrast, there was no
effect of WA on plasma DHA and omega-6 fatty acids (n-6). Finally, both n-3 and n-6 in the liver
remained
unchanged by the WA.
Conclusion: These results suggest that WA consumption has a significant effect on EPA in plasma
without
affecting n-6. Subsequent studies are required to examine whether these effects may explain partly
the health
benefits associated with whole wheat consumption.