Sammanfattning
Background. We tested the hypothesis that uric acid levels are higher in subjects with schizophrenia
treated with clozapine than in healthy control and they correlate with anthropometric measurements,
laboratory tests and results of bioimpedance analysis of body composition. Methods. Data for 24
subjects with schizophrenia treated with clozapine and 24 age- and sex-matched healthy volunteers
was analyzed. Results. There was no difference of fasting uric acid concentrations between
clozapine and control groups (4.5 ± 1.4 vs. 4.3 ± 1.3 mg/dl, P = 0.87). Regarding the whole group, uric
acid levels were significantly higher in men (5.2 ± 1.2 vs. 3.6 ± 0.9, P < 0.001). Uric acid levels
correlated with weight (R = 0.58, P = 0.003), body mass index (BMI; R = 0.49, P = 0.01), abdominal
circumference (R = 0.45, P = 0.03), waist circumference (R = 0.47, P = 0.02), waist-to-hip ratio (R =
0.42, P = 0.04), insulin (R = 0.50, P = 0.01), homoeostasis model assessment of insulin resistance 2
(HOMA2-IR; R = 0.49, P = 0.01), basal metabolic rate (R = 0.56, P = 0.004), lean body mass (R = 0.55,
P = 0.005) and body water (R = 0.55, P = 0.005). There were no significant differences of uric acid
levels for smoking status, impaired fasting glucose, abdominal obesity, obesity/overweight and
dyslipidemia. Uric acid levels did not correlate with age, duration of clozapine treatment, clozapine
dose, leg circumference, systolic blood pressure, diastolic blood pressure, total body fat,
triglycerides, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL),
homocysteine, corrected calcium, glucose and homoeostasis model assessment of insulin
resistance 1 (HOMA1-IR). Conclusions. We did not find significant differences in blood uric acid
levels between subjects with schizophrenia and controls. Association with weight, BMI, abdominal
and waist circumferences, insulin levels and insulin resistance may support uric acid role as an
important cardiovascular risk factor. Association with lean weight may explain why men have higher
levels of uric acid than women.