Sammanfattning
Background and aims: Treatment adherence is one of the most important factors that may
determine treatment response in patients with bipolar disorders (BD). Many factors have been
described to be associated with treatment adherence in BD. Temperament that can influence the
course of BD will have an impact on treatment adherence. The aim of this study is to investigate
temperament effect on treatment adherence in euthymic patients with BD-I. Methods: Eighty patients
with BD-I participated in the study. A psychiatrist used the Structured Clinical Interview for DSM-IV
Axis-I Disorders to determine the diagnosis and co-morbidities. Hamilton Depression and Young
Mania Rating Scale were used to detect the remission. We used the Temperament Evaluation of
Memphis, Pisa, Paris, San Diego Autoquestionnaire and the 4-item Morisky Medication Adherence
Scale to evaluate temperament and treatment adherence, respectively. The study group was divided
into two groups as "treatment adherent" and "treatment non-adherent". Results: The cyclothymic and
anxious temperament scores of the treatment non-adherent patients with BD-I were significantly
higher than those of the treatment adherent group (p < 0.001, p = 0.006, respectively). Multiple linear
regression analysis determined that cyclothymic temperament predicted treatment non-adherence (p
= 0.009). Conclusion: It should be kept in mind that BD-I patients with cyclothymic temperament may
be treatment non-adherent and future studies should explore whether temperament characteristics
deteriorate BD-I course by disrupting treatment adherence.