Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders
Engelsk titel: Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders
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Författare:
Clerici, Massimo
;
Castellano, Filippo
;
Bartoli, Francesco
;
Carrà,Giuseppe
;
Crocamo, Cristina
;
Papagno, Costanza
;
Lax, Annamaria
;
Amidani, Francesca
;
Nicolini, Gabriella
;
Chiorazzi, Alessia
;
Gamba, Giulia
Email: cristina.crocamo@unimib.it
Språk: Eng
Antal referenser: 55
Dokumenttyp:
Artikel
UI-nummer: 17080058
Sammanfattning
Background: A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met)
appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those
with psychosis.
Methods: To explore the potential moderating effect of these factors, a cross-sectional study was conducted,
randomly recruiting subjects with DSM-IV diagnosis of schizophrenia. AUD/SUD was rigorously
assessed, as well as COMT Val158Met polymorphism. Executive control functioning was measured using
the Intra-Extra Dimensional Set Shift (IED). The effect of a possible interaction between comorbid AUD/
SUD and COMT Val158Met polymorphism on IED scores was explored.
Results: Subjects with schizophrenia, comorbid AUD/SUD, and MetMet carriers for SNP rs4680 of the
COMT gene showed worse performance on IED completed stages scores, as compared with individuals
with ValVal genotype. However, among subjects without AUD/SUD, those with the MetMet variant performed
better than people carrying ValVal genotype.
Conclusions: This study is the first to date examining the impact of COMT on cognition in a highly
representative sample of people with schizophrenia and comorbid AUD/SUD. Differential moderating
effects of COMT Val/Met genotype variations may similarly influence executive functions in people with
schizophrenia and comorbid AUD/SUD