COX-2-selektive haemmere - bivirkningsprofil i forhold til uspecifikke nonsteroide antiinflammatoriske praeparater
Engelsk titel: Selective COX-2 inhibitors - side effects in relation to non-specific non-steroidal anti-inflammatory drugs
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Författare:
Möller Hansen J
;
Schaffalitzky de Muckadell OB
Email: jane.hansen@dadlnet.dk
Språk: Dan
Antal referenser: 18
Dokumenttyp:
Översikt
UI-nummer: 04121687
Sammanfattning
COX-2 inhibitors were developed with the purpose of reducing the gastrointestinal side effects connected with the use of non-steroidal anti-inflammatory drugs (NSAIDs). COX-2 inhibitors have been demonstrated to reduce the risk of ulcers and probably also of ulcer complications as compared to non-specific NSAIDs. Patients at increased risk of peptic ulcer will probably benefit from the COX-2 inhibitors; other patients, however, can use the less expensive non-specific NSAIDs without substantial risk. Caution in using COX-2 inhibitors is recommended for some patients: those treated with low-dose aspirin, since aspirin eliminates the protective effects of COX-2 inhibitors; those with a previous bleeding ulcer, since the risk for rebleeding is relatively high during treatment with COX-2 inhibitors, as well as with non-specific NSAIDs combined with proton-pump inhibitors; and those with cardiovascular disease, since COX-2 inhibitors, as well as non-specific NSAIDs, rise the blood pressure, cause water retention, increase the risk of cardiac incompensation, and possibly increase the risk of thromboembolic events, as has been shown for rofecoxib.