Risiko for anastomoselaekage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer
Engelsk titel: Risk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs
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Författare:
Klein, Mads
;
Gögenur, Ismail
;
Rosenberg, Jacob
Email: madsklein@hotmail.com
Språk: Dan
Antal referenser: 20
Dokumenttyp:
Artikel
UI-nummer: 10061253
Sammanfattning
Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis.