RNA-interferens - vejen til individualiseret genetisk medicin
Engelsk titel: RNA interference - toward individualized genetic medicine
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Författare:
Corydon TJ
;
Giehm Mikkelsen J
Email: giehm@humgen.au.dk
Språk: Dan
Antal referenser: 10
Dokumenttyp:
Översikt
UI-nummer: 06121506
Sammanfattning
RNA interference (RNAi) is an evolutionarily conserved cellular mechanism by which gene expression is suppressed by double-stranded RNA (dsRNA) in a sequence-specific manner. Enzymatically processed dsRNA molecules (siRNAs) target and facilitate cleavage of mRNA. By harnessing the RNAi machinery using synthetic or DNA-encoded RNA effectors, the siRNA technology offers new therapeutic strategies for genetic diseases. We outline the basic mechanisms of RNAi and present state-of-the-art examples of in vivo siRNA delivery towards development of RNAi-based individualized drugs.