Status og perspektiver for behandling af de kroniske myeloproliferative neoplasier
Engelsk titel: Status and perspectives on chronic myeloproliferative neoplasm treatment
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Författare:
Ocias, Lukas Frans
;
Holmström, Morten Orebo
;
Riley, Caroline Hasselbalch
;
Lykkegaard Andersen, Christen
;
Rönnov-Jessen, Dorte
;
Starklint, Jörn
;
Frederiksen, Mikael
;
Saabye Steffensen, Morten
;
Bjerrum, Ole Weis
;
Farmer, Sarah
;
Mourits-Andersen, Torben
;
Hasselbalch, Hans Carl
;
Stauffer Larsen, Thomas
Email: hans.hasselbalch@dadlnet.dk
Språk: Dan
Antal referenser: 30
Dokumenttyp:
Översikt
UI-nummer: 16037126
Sammanfattning
Polycythaemia vera, essential thrombocytosis and primary myelofibrosis are closely related, clonal myeloproliferative neoplasms. Our knowledge of the underlying molecular
mechanisms driving these diseases has increased dramatically during the latest ten years. Traditionally, treatment of these malignancies has focused on lowering their inherent
thromboembolic risk but with the discovery of the JAK2-V617F mutation and most recently the calreticulin mutations new therapeutic options such as interferon-alpha, JAK2-inhibitors and
statins are being contemplated. This article reviews these new treatment options.