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Nye molekylaere markörer ved de kroniske myeloproliferative sygdomme. I. PRV1-gen
Engelsk titel: New molecular markers within the chronic myeloproliferative disorders. I: The PRV1 gene Läs online Författare: Stauffer Larsen T ; Pallisgaard N ; Haaber Christensen J ; Gram-Hansen P ; Kerndrup GB ; Möller MB ; Hasselbalch HC Språk: Dan Antal referenser: 39 Dokumenttyp: Översikt UI-nummer: 06091988


Ugeskrift for Laeger 2006;168(39)3295-9 ISSN 0041-5782 E-ISSN 1603-6824 KIBs bestånd av denna tidskrift Denna tidskrift är expertgranskad (Peer-Reviewed)


PRV-1 is a new molecular marker within the Ph-negative chronic myeloproliferative disorders. PRV-1 is a useful, highly sensitive and specific marker in the differentiation between polycythaemia vera (PV) and secondary erythrocytosis (ET), and seems to identify those PV patients presenting in the early phase of the disease with dominating thrombocytosis and thus a clinical phenotype of ET. These PRV-1 positive ET patients can be regarded as having ``masked'' PV or, more accurately, as having early PV. Moreover, PRV-1 positivity may be associated with a particular risk of thromboembolic complications. The biological role of PRV-1 and the significance of alterations in PRV-1 gene expression levels during treatment remain to be clarified.